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The concomitant usage of ROXICODONE and CYP3A4 inhibitors can increase the plasma concentration of oxycodone, leading to amplified or extended opioid effects. These outcomes may be much more pronounced with concomitant usage of ROXICODONE and CYP2D6 and CYP3A4 inhibitors, especially when an inhibitor is additional after a steady dose of ROXICODONE